Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.47 |
| ▸ | TSHR | P16473 | 14/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.46 |
| ▸ | USP2 | O75604 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571730 | 0.84 | MEN1 (0.44) | HSD17B10MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31123781 | 0.78 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL21682074 | 0.78 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30908317 | 0.75 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL789612 | 0.74 | MEN1 (0.44) | HSD17B10MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30908144 | 0.74 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL31511351 | 0.74 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30908447 | 0.72 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30908321 | 0.72 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30908690 | 0.72 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12173026-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-12-24 | — | — | US | disclosed |
| CN-112805006-B | PRMT5 inhibitors | 默沙东有限责任公司 | 2024-09-24 | — | — | CN | disclosed |
| US-20230062119-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME LLC (US) | 2023-03-02 | — | — | US | disclosed |
| US-20220363707-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-11-17 | — | — | US | disclosed |
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3833355-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-16 | — | — | EP | disclosed |
| CN-112805006-A | PRMT5 inhibitor | 默沙东公司 | 2021-05-14 | — | — | CN | disclosed |
| WO-2020033288-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363707-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | CYP1A2 1814/4885CYP3A4 1162/4885CYP2C19 703/4885 |
| US-12173026-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | CYP1A2 1814/4885CYP3A4 1162/4885CYP2C19 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.