Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.69 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA7 | P43166 | 2/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31123708 | 1.00 | PSMB8 (0.69) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL7635377 | 0.87 | PSMB8 (0.65) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL2711265 | 0.83 | PSMB8 (0.75) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL10047096 | 0.83 | PSMB8 (0.64) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL30817868 | 0.82 | PSMB8 (1.00) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL29164335 | 0.82 | PSMB8 (1.00) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL24214020 | 0.81 | PSMB8 (0.56) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL11782646 | 0.79 | PSMB8 (0.68) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL329577 | 0.78 | PSMB8 (0.72) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL8890882 | 0.78 | NPC1 (0.45) | PSMB8PSMB5CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230062119-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME LLC (US) | 2023-03-02 | — | — | US | disclosed |
| CN-108164475-B | Method for catalytic synthesis of difluoromethyl-substituted linear aryl hetero-ketone | 南京工业大学 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021126999-A1 | USE OF BIOMARKERS IN IDENTIFYING PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3833355-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020033288-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
| CN-108164475-A | Method for catalytic synthesis of difluoromethyl-substituted linear aryl hetero-ketone | 南京工业大学 | 2018-06-15 | — | — | CN | disclosed |
| CN-104356032-A | Preparation method for fluorine-containing sulfinate | SHANGHAI INST ORGANIC CHEM | 2015-02-18 | — | — | CN | disclosed |