⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10950637 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL28575007 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL6381540 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL28576746 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL28914313 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL8032226 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL1199470 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL4238846 | 1.00 | ALDH1A1 (0.60) | — | |
| SCHEMBL2167079 | 0.97 | — | — | |
| SCHEMBL437912 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211414-B2 | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity | VISIGEN BIOTECHNOLOGIES, INC. (US) | 2007-05-01 | — | — | US | claimed |
| US-11464866-B2 | Pharmaceutical composition containing macromolecular drug | BIODYNAMIC RESEARCH FOUNDATION (JP) | 2022-10-11 | — | — | US | disclosed |
| CN-109069472-B | Pharmaceutical composition containing high-molecular drug | 一般财团法人生物动力学研究所 | 2022-01-04 | — | — | CN | disclosed |
| US-20180100191-A1 | ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR INHIBITING PYROPHOSPHOROLYSIS | VISIGEN BIOTECHNOLOGIES, INC. | 2018-04-12 | — | — | US | disclosed |
| US-9845500-B2 | Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis | Life Technologies Corporation (US) | 2017-12-19 | — | — | US | disclosed |
| US-20160244822-A1 | ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR INHIBITING PYROPHOSPHOROLYSIS | Life Technologies Corporation | 2016-08-25 | — | — | US | disclosed |
| US-9243284-B2 | Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis | Life Technologies Corporation (US) | 2016-01-26 | — | — | US | disclosed |
| US-9139456-B2 | Chelating compounds and immobilized tethered chelators | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2015-09-22 | — | — | US | disclosed |
| US-20140127781-A1 | ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR INHIBITING PYROPHOSPHOROLYSIS | Life Technologies Corporation (US) | 2014-05-08 | — | — | US | disclosed |
| US-8648179-B2 | Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis | Life Technologies Corporation (US) | 2014-02-11 | — | — | US | disclosed |
| US-5874554-A | DISPENSING A MIXTURE OF ACETONITRILE WITH A STABILIZING CO-SOLVENT WHICH IS AN ORGANIC SOLVENT HAVING A BOILING POINT OR FLASH POINT GREATER THAN ABOUT 100.DEGREE. C., AND IS MISCIBLE WITH ACETONITRILE | INCYTE PHARMACEUTICALS, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| WO-1998025944-A1 | SOLVENT VEHICLES FOR REAGENT DELIVERY IN OLIGONUCLEOTIDE SYNTHESIS USING AUTOMATED PULSE JETTING DEVICES | INCYTE PHARMACEUTICALS, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| US-5268272-A | Water soluble complexes | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-07 | — | — | US | disclosed |
| EP-0063323-B1 | 5-SUBSTITUTED 4-OXO-PGI1 DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1985-10-30 | — | — | EP | disclosed |
| US-4520018-A | 5-Substituted-4-oxo-PGI1 derivatives, PGI1 compounds of similar structure, their pharmaceutical methods and process for the preparation of said compounds | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1985-05-28 | — | — | US | disclosed |
| EP-0063323-A1 | 5-Substituted 4-oxo-PGI1 derivatives, their preparation and pharmaceutical compositions | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1982-10-27 | — | — | EP | disclosed |
| US-4342711-A | EXTRUDING A SPINNING SOLUTION OF POLYMER AND SOLVENT AROUND A STREAM OF SOLVENT AND SWELLING LIQUID; INTO AN AQUEOUS BATH HIGH SPEED | NIPPON ZEON CO., LTD. (JP) | 1982-08-03 | — | — | US | disclosed |
| US-4323627-A | CONTROLLED HYDROLYSI USING ALKALI OR ACID | NIPPON ZEON CO., LTD. (JP) | 1982-04-06 | — | — | US | disclosed |
| US-4322381-A | Method of manufacturing hollow fiber | NIPPON ZEON CO., LTD. (JP) | 1982-03-30 | — | — | US | disclosed |
| US-3951754-A | Method of inhibiting the thermopolymerization of isoprene and butadiene | LIAKUMOVICH ALEXANDR GRIGORIEV | 1976-04-20 | — | — | US | disclosed |