Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683301 | 1.00 | LMNA (0.45) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL7864202 | 0.81 | PRSS1 (0.50) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL27207830 | 0.77 | KMT2A (0.49) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL335254 | 0.77 | MEN1 (0.50) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL15328453 | 0.77 | MEN1 (0.50) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL29573114 | 0.75 | GRM2 (0.42) | LMNAMEN1KMT2AL3MBTL1HDAC1 | |
| SCHEMBL6791575 | 0.75 | GRM2 (0.42) | LMNAMEN1KMT2AL3MBTL1HDAC1 | |
| SCHEMBL18527956 | 0.75 | MEN1 (0.51) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL356816 | 0.75 | MEN1 (0.51) | LMNAMEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL20836738 | 0.75 | HDAC1 (0.40) | LMNAMEN1KMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20240279206-A1 | Modulators of RAS GTPase | TOSK, INC. | 2024-08-22 | — | — | US | disclosed |
| US-11945803-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | LMNA 3457/4885MEN1 503/4885KMT2A 3199/4885 |
| US-11945803-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | LMNA 3457/4885MEN1 503/4885KMT2A 3199/4885 |
| US-20240279206-A1 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | LMNA 3457/4885MEN1 503/4885KMT2A 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.