Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683414 | 1.00 | MGAM (0.33) | MGAMCA1CA2GAASI | |
| SCHEMBL14296872 | 1.00 | MGAM (0.33) | MGAMCA1CA2GAASI | |
| SCHEMBL12561443 | 0.82 | MGAM (0.31) | MGAMCA1CA2GAASI | |
| SCHEMBL14296875 | 0.82 | MGAM (0.31) | MGAMCA1CA2GAASI | |
| SCHEMBL14477541 | 0.82 | MGAM (0.31) | MGAMCA1CA2GAASI | |
| SCHEMBL24509722 | 0.81 | MGAM (0.30) | MGAMCA1CA2GAASI | |
| SCHEMBL23288114 | 0.81 | MGAM (0.30) | MGAMCA1CA2GAASI | |
| SCHEMBL5361406 | 0.74 | LMNA (0.35) | — | |
| SCHEMBL17752954 | 0.74 | LSS (0.36) | — | |
| SCHEMBL19124422 | 0.74 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833668-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |
| US-11993602-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-05-28 | — | — | US | disclosed |
| US-11834470-B2 | 4-thioribose NAD analogues and methods of synthesizing and using the same | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834470-B2 | 4-thioribose NAD analogues and methods of synthesizing and using the same | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834470-B2 | 4-thioribose NAD analogues and methods of synthesizing and using the same | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220227803-A1 | 4-THIORIBOSE NAD ANALOGUES AND METHODS OF SYNTHESIZING AND USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-07-21 | — | — | US | disclosed |
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
| EP-3833668-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020033282-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834470-B2 | 4-thioribose NAD analogues and methods of synthesizing and using the same | CD38, NQO1, NADK | MGAM 597/4885CA1 2959/4885CA2 3622/4885 |
| US-20220227803-A1 | 4-THIORIBOSE NAD ANALOGUES AND METHODS OF SYNTHESIZING AND USING THE SAME | CD38, NQO1, NADK | MGAM 597/4885CA1 2959/4885CA2 3622/4885 |
| US-11993602-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT6 | MGAM 2991/4885CA1 4036/4885CA2 3910/4885 |
| US-20210277009-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | MGAM 2991/4885CA1 4036/4885CA2 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.