SCHEMBL21687652

SCHEMBL21687652

N#Cc1ccc([Si](c2ccccc2)(c2ccccc2)c2ccccc2)c(C#N)c1-c1ccccc1-n1c2ccccc2c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.34
HIF1A Q16665 1/20 0.34
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
ALDH1A1 P00352 5/20 0.33
TSHR P16473 3/20 0.32
HSD17B10 Q99714 1/20 0.32
AR P10275 1/20 0.32
IMPDH2 P12268 1/20 0.31
KDM4E B2RXH2 1/20 0.31
TDP1 Q9NUW8 2/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
SLC22A12 Q96S37 1/20 0.30
NPC1 O15118 1/20 0.30
GLA P06280 1/20 0.30
GAA P10253 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21687808 0.92 HRH1 (0.34) HTR2AHTR2C
SCHEMBL21687645 0.86 AR (0.34) SMN1; SMN2HIF1AHTR2AHTR2CALDH1A1
SCHEMBL21687980 0.86 SMN1; SMN2 (0.35) SMN1; SMN2HIF1AALDH1A1TSHRAR
SCHEMBL21687769 0.85 SMN1; SMN2 (0.38) SMN1; SMN2HIF1AHTR2AHTR2CALDH1A1
SCHEMBL21688229 0.84 ALDH1A1 (0.35) SMN1; SMN2HIF1AALDH1A1TSHRKDM4E
SCHEMBL21688167 0.84 ALDH1A1 (0.35) SMN1; SMN2HIF1AALDH1A1TSHRAR
SCHEMBL21688265 0.84 SMN1; SMN2 (0.33) SMN1; SMN2HIF1AALDH1A1ARKDM4E
SCHEMBL21687764 0.84 SMN1; SMN2 (0.41) SMN1; SMN2HIF1AHTR2AHTR2CALDH1A1
SCHEMBL21687985 0.83 ALDH1A1 (0.35) SMN1; SMN2HIF1AALDH1A1KDM4EMAPK1
SCHEMBL21687781 0.82 SMN1; SMN2 (0.37) SMN1; SMN2HIF1AALDH1A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2021-12-14 US disclosed
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-02-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND CRY1, CCNL2, CCNE2 SMN1; SMN2 4039/4885HIF1A 622/4885HTR2A 3207/4885
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound CRY1, CCNL2, CCNE2 SMN1; SMN2 4039/4885HIF1A 622/4885HTR2A 3207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.