Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168977 | 1.00 | IDH1 (0.46) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL2169217 | 1.00 | IDH1 (0.46) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL4708150 | 0.90 | IDH1 (0.50) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL1154453 | 0.90 | IDH1 (0.50) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL1154754 | 0.90 | IDH1 (0.50) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL1154459 | 0.90 | IDH1 (0.50) | IDH1HSD11B1EPHX2ALDH1A1GAA | |
| SCHEMBL2168938 | 0.86 | CA12 (0.44) | HSD11B1EPHX2ALDH1A1GAACPB1 | |
| SCHEMBL2168844 | 0.86 | CA12 (0.44) | HSD11B1EPHX2ALDH1A1GAACPB1 | |
| SCHEMBL2168847 | 0.86 | CA12 (0.44) | HSD11B1EPHX2ALDH1A1GAACPB1 | |
| SCHEMBL2168826 | 0.84 | EPHX2 (0.58) | HSD11B1EPHX2ALDH1A1GAACPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252781-B2 | 1,2-diazetidin-3-one derivatives and drugs containing same | KOWA COMPANY, LTD. (JP) | 2012-08-28 | — | — | US | disclosed |
| EP-2348019-A1 | 1,2-DIAZETIDIN-3-ONE DERIVATIVE AND PHARMACEUTICAL AGENT COMPRISING SAME | Kowa Company, Ltd. (JP) | 2011-07-27 | — | — | EP | disclosed |
| US-20100144694-A1 | 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME | KOWA COMPANY, LTD. (JP) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144694-A1 | 1,2-DIAZETIDIN-3-ONE DERIVATIVES AND DRUGS CONTAINING SAME | HSD11B1, HSD11B2, HSD3B1 | IDH1 430/4885HSD11B1 1/4885EPHX2 2371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.