Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874955 | 0.81 | DPP4 (0.42) | — | |
| SCHEMBL10510105 | 0.76 | MC4R (0.52) | SMN1; SMN2HPGDALDH1A1L3MBTL1KDM4E | |
| SCHEMBL10510159 | 0.76 | MC4R (0.52) | SMN1; SMN2HPGDALDH1A1L3MBTL1KDM4E | |
| SCHEMBL22291794 | 0.71 | POLB (0.52) | SMN1; SMN2HPGDNPC1ALDH1A1GAA | |
| SCHEMBL14273591 | 0.70 | DPP4 (0.41) | L3MBTL1 | |
| SCHEMBL4589694 | 0.70 | POLB (0.37) | L3MBTL1 | |
| SCHEMBL12324861 | 0.70 | DPP4 (0.41) | L3MBTL1 | |
| SCHEMBL21696674 | 0.69 | VHL (0.50) | CCNE1CDK2 | |
| SCHEMBL24785479 | 0.69 | GSK3B (0.42) | SMN1; SMN2HPGDALDH1A1L3MBTL1GAA | |
| SCHEMBL26579311 | 0.69 | PLA2G7 (0.43) | SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |