Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 5/20 | 0.54 |
| ▸ | ELOC | Q15369 | 3/20 | 0.54 |
| ▸ | ELOB | Q15370 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16277209 | 0.94 | VHL (0.57) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL21696667 | 0.91 | PKM (0.58) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL15126384 | 0.91 | VHL (0.59) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL15126261 | 0.90 | VHL (0.59) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL15126003 | 0.90 | VHL (0.53) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL21696687 | 0.90 | VHL (0.59) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL21696951 | 0.90 | ALDH1A1 (0.56) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL21697385 | 0.90 | VHL (0.53) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL21696577 | 0.89 | VHL (0.55) | VHLELOCELOBPKMCYP3A4 | |
| SCHEMBL15126157 | 0.88 | VHL (0.52) | VHLELOCELOBPKMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |