Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ELOC | Q15369 | 3/20 | 0.39 |
| ▸ | ELOB | Q15370 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21696612 | 0.91 | VHL (0.51) | VHLMEN1KMT2APOLBELOC | |
| SCHEMBL15126061 | 0.84 | VHL (0.56) | VHLELOCELOBMAPTALDH1A1 | |
| SCHEMBL15126261 | 0.81 | VHL (0.59) | VHLMEN1KMT2APOLBELOC | |
| SCHEMBL21696687 | 0.81 | VHL (0.59) | VHLMEN1KMT2APOLBELOC | |
| SCHEMBL16277211 | 0.79 | VHL (0.57) | VHLMEN1KMT2APOLBELOC | |
| SCHEMBL21697390 | 0.77 | VHL (0.69) | VHLELOCELOB | |
| SCHEMBL15125903 | 0.77 | VHL (0.69) | VHLELOCELOB | |
| SCHEMBL15126072 | 0.77 | VHL (0.69) | VHLPOLBELOCELOBSMN1; SMN2 | |
| SCHEMBL21697138 | 0.73 | CCNE1 (0.47) | VHL | |
| SCHEMBL21696667 | 0.73 | PKM (0.58) | VHLELOCELOBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |