Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 7/20 | 0.47 |
| ▸ | CDK2 | P24941 | 7/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | VHL | P40337 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21696439 | 0.84 | CCNE1 (0.54) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL21696556 | 0.84 | CCNE1 (0.54) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL21696706 | 0.80 | CCNE1 (0.54) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL15112607 | 0.74 | VHL (0.55) | CCNE1CDK2GSK3BVHLCHRNB2 | |
| SCHEMBL21696532 | 0.73 | VHL (0.43) | VHL | |
| SCHEMBL15126220 | 0.72 | VHL (0.53) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL21696674 | 0.72 | VHL (0.50) | CCNE1CDK2GSK3BVHLEPHX2 | |
| SCHEMBL21696738 | 0.71 | VHL (0.52) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL13570435 | 0.71 | VHL (0.52) | CCNE1CDK2GSK3BVHL | |
| SCHEMBL21696618 | 0.69 | VHL (0.53) | CCNE1CDK2GSK3BVHL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |