Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15125995 | 0.83 | VHL (0.54) | SMN1; SMN2CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21696581 | 0.82 | POLB (0.56) | POLBF2CYP3A4CYP2C9PKM | |
| SCHEMBL22291794 | 0.82 | POLB (0.52) | POLBSMN1; SMN2F2CYP3A4CYP2C9 | |
| SCHEMBL21696530 | 0.82 | CYP3A4 (0.59) | POLBF2CYP3A4CYP2C9PKM | |
| SCHEMBL16277177 | 0.81 | POLB (0.51) | POLBF2CYP3A4CYP2C9PKM | |
| SCHEMBL16277225 | 0.81 | POLB (0.51) | POLBF2CYP3A4CYP2C9PKM | |
| SCHEMBL16277175 | 0.79 | POLB (0.51) | POLBF2CYP3A4CYP2C9PKM | |
| SCHEMBL13272490 | 0.78 | FKBP1A (0.48) | POLBALDH1A1FNTAFNTB | |
| SCHEMBL30874798 | 0.78 | VNN1 (0.62) | POLBCYP3A4CYP2C9ALDH1A1FNTA | |
| SCHEMBL21696811 | 0.78 | POLB (0.56) | POLBF2CYP3A4CYP2C9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |