Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817767 | 0.84 | BDKRB2 (0.44) | BDKRB2MAOAMAOBKCNH2 | |
| SCHEMBL29233149 | 0.82 | ESR1 (0.53) | BDKRB2ESR1ESR2ADORA3CHRM1 | |
| SCHEMBL20226533 | 0.82 | MAPT (0.46) | BDKRB2MAOAMAOBCSNK1E | |
| SCHEMBL6824286 | 0.82 | CSNK1E (0.49) | MAOACSNK1ECTSKCTSLCTSB | |
| SCHEMBL12427784 | 0.79 | SLC6A4 (0.55) | SIGMAR1 | |
| SCHEMBL28758567 | 0.79 | ESR1 (0.50) | BDKRB2ESR1ESR2ADORA3CHRM1 | |
| SCHEMBL10497016 | 0.78 | BDKRB2 (0.39) | BDKRB2MAOAMAOBESR1ESR2 | |
| SCHEMBL8771698 | 0.78 | CYP3A4 (0.48) | BDKRB2MAOAMAOBCSNK1E | |
| SCHEMBL28407916 | 0.78 | BDKRB2 (0.40) | BDKRB2MAOAMAOBCSNK1ECTSK | |
| SCHEMBL29038971 | 0.78 | CYP2A6 (0.50) | BDKRB2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |