Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | AOC2 | O75106 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888632 | 0.82 | HRH2 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17888615 | 0.82 | PDE4D (0.38) | AOC2 | |
| SCHEMBL17931460 | 0.82 | PDE4D (0.40) | ALDH1A1MAPT | |
| SCHEMBL21697493 | 0.76 | ATF4 (0.36) | HPGDALDH1A1MAPTFDPSSMN1; SMN2 | |
| SCHEMBL17888612 | 0.75 | PDE4D (0.39) | — | |
| SCHEMBL31364354 | 0.72 | HPGD (0.52) | HPGDALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL17899128 | 0.72 | PDE4D (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17888597 | 0.72 | PDE4D (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17888594 | 0.72 | PDE4D (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL21697491 | 0.69 | CYSLTR2 (0.35) | HPGDALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |