Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17899157 | 0.85 | PDE4D (0.39) | CYSLTR2PDE4D | |
| SCHEMBL21697493 | 0.82 | ATF4 (0.36) | ACACBALDH1A1PDE4DLMNAMAPT | |
| SCHEMBL17899132 | 0.74 | MAPT (0.41) | ALDH1A1LMNAMAPTHPGDPOLB | |
| SCHEMBL17931463 | 0.74 | ALDH1A1 (0.42) | ALDH1A1PDE4DMAPTL3MBTL1HRH3 | |
| SCHEMBL17888567 | 0.73 | OPRK1 (0.39) | PDE4D | |
| SCHEMBL21697488 | 0.73 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL17888542 | 0.73 | SLC6A2 (0.40) | ACACBHPGDRAB9APPARGPPARA | |
| SCHEMBL31662412 | 0.72 | DRD4 (0.35) | CYSLTR2ACACBADRB3PLA2G4A | |
| SCHEMBL17888598 | 0.72 | PARP10 (0.38) | ALDH1A1PDE4DMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL31662099 | 0.71 | JAK1 (0.35) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |