Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17700812 | 0.87 | KMT2A (0.39) | CA1CA2CA12CA9CHRNA7 | |
| SCHEMBL21700027 | 0.87 | MAPT (0.40) | CA1CA2CA12CA9CHRNA7 | |
| SCHEMBL16236608 | 0.86 | BAZ2B (0.40) | CA1CA2CA12CA9CHRNA7 | |
| SCHEMBL22007929 | 0.83 | CA1 (0.48) | CA1CA2CA12CA9CHRNA7 | |
| SCHEMBL22008225 | 0.82 | STS (0.43) | CA1CA2CA12CA9STS | |
| SCHEMBL16237225 | 0.81 | LMNA (0.38) | CA1CA2KMT2AMEN1LMNA | |
| SCHEMBL16992971 | 0.80 | POLB (0.37) | KMT2ALMNAGAATSHRHSD17B10 | |
| SCHEMBL16237218 | 0.79 | PDK1 (0.36) | KMT2ALMNAGAAALOX15TSHR | |
| SCHEMBL18261880 | 0.79 | PDK1 (0.36) | KMT2ALMNAGAAALOX15TSHR | |
| SCHEMBL17700858 | 0.79 | PDK1 (0.36) | KMT2ALMNAGAAALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020030781-A1 | TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2020-02-13 | — | — | WO | disclosed |
| EP-3608326-A1 | TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS | IRBM S.P.A. (IT) | 2020-02-12 | — | — | EP | disclosed |