Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 16/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 11/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.38 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.38 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | GGT1 | P19440 | 2/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197432 | 0.76 | GRIK1 (0.45) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL1512923 | 0.72 | GRIK1 (0.59) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL1512922 | 0.72 | GRIK1 (0.59) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL25660458 | 0.72 | GRIK1 (0.59) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL24489604 | 0.70 | GRIK1 (0.47) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL14197863 | 0.70 | — | — | |
| SCHEMBL26792990 | 0.70 | GRIK1 (0.52) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL13176623 | 0.69 | GRIK1 (0.43) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL28261447 | 0.68 | GRIK1 (0.54) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL10585579 | 0.67 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480247-B1 | NOVEL NPR-B AGONISTS | SHIRE ORPHAN THERAPIES GMBH (DE) | 2020-02-12 | — | — | EP | disclosed |