Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219748 | 0.83 | NPC1 (0.51) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL29563253 | 0.83 | NPC1 (0.51) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL4215654 | 0.81 | NPC1 (0.50) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL20142746 | 0.79 | NOTUM (0.41) | KDM4EMAPTNISCHSMN1; SMN2HIF1A | |
| SCHEMBL18151670 | 0.79 | NPC1 (0.42) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL11281747 | 0.78 | MAPK1 (0.53) | NPC1MAPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL2170098 | 0.77 | TSHR (0.44) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL26078395 | 0.77 | NPC1 (0.43) | NPC1MAPK1MPOKDM4EMEN1 | |
| SCHEMBL9234254 | 0.76 | CYP19A1 (0.39) | KDM4ELMNAGAANISCHSMN1; SMN2 | |
| SCHEMBL17194959 | 0.75 | MAPK1 (0.50) | NPC1MAPK1MPOKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108463461-A | Cephem compounds, its preparation and use | 奈加-RGM制药有限公司 | 2018-08-28 | — | — | CN | disclosed |
| CN-105683194-A | (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones as inhibitors of fibrinolysis | 拜耳制药股份公司 | 2016-06-15 | — | — | CN | disclosed |
| US-20130281455-A1 | Phenylpyri(mi)dinylazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-24 | — | — | US | disclosed |
| US-20110183978-A1 | Phenylpyri(mi)dinylazoles | BAYER CROPSCIENCE AG (DE) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281455-A1 | Phenylpyri(mi)dinylazoles | PIR, PIN4, PNN | NPC1 3221/4885MAPK1 1606/4885MPO 206/4885 |
| US-20110183978-A1 | Phenylpyri(mi)dinylazoles | PIR, PIN4, PNN | NPC1 3221/4885MAPK1 1606/4885MPO 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.