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PIN4

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 · Q9Y237 · PIN4 on Sugi Atlas →

865 patent compounds predicted against PIN4, 503 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL442751 SCHEMBL442751 1.00 1/20
SCHEMBL444334 SCHEMBL444334 0.88 1/20
SCHEMBL18348920 SCHEMBL18348920 0.85 1/20
SCHEMBL11453331 SCHEMBL11453331 0.76 1/20
SCHEMBL11395567 SCHEMBL11395567 0.75 1/20
SCHEMBL22140316 SCHEMBL22140316 0.74 1/20
SCHEMBL521934 SCHEMBL521934 0.70 1/20
SCHEMBL522944 SCHEMBL522944 0.68 1/20
SCHEMBL523511 SCHEMBL523511 0.68 1/20
SCHEMBL10819259 SCHEMBL10819259 0.68 1/20
SCHEMBL523639 SCHEMBL523639 0.68 1/20
SCHEMBL22140309 SCHEMBL22140309 0.66 1/20
SCHEMBL522710 SCHEMBL522710 0.62 1/20
SCHEMBL6061073 SCHEMBL6061073 0.62 1/20
SCHEMBL11407615 SCHEMBL11407615 0.62 1/20
SCHEMBL24909289 SCHEMBL24909289 0.61 1/20
SCHEMBL25175089 SCHEMBL25175089 0.61 1/20
SCHEMBL30503187 SCHEMBL30503187 0.61 1/20
SCHEMBL1657024 SCHEMBL1657024 0.60 1/20
SCHEMBL1989875 SCHEMBL1989875 0.60 1/20

Clinical trials — most relevant to PIN4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab PHASE4UNKNOWN
The Effectiveness of Kuvan in Amish PKU Patients PHASE4COMPLETED
Implementation of Molecular Diagnostic Pathways nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Identification of Acute Intermittent Porphyria Modifying Genes nanRECRUITING
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING
Metabolic Profiling of Immune Responses in Immune-mediated Diseases nanRECRUITING
Pain In Neuropathy Study nanUNKNOWN
Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular Disease nanCOMPLETED
Characterizing Protein Biomarkers of Post-infection Irritable Bowel Syndrome nanCOMPLETED
Clubfoot DNA Repository nanCOMPLETED
Clinical Diagnosis of Acute Porphyria nanCOMPLETED
Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact nanCOMPLETED
Quantification of GADD34 Expression in RA nanCOMPLETED
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects) nanUNKNOWN
Cerebellar Mutism Syndrome Study nanRECRUITING
Developing Newborn Screening for Infants With Primary Immunodeficiency nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Genetic Analysis of Parkinson's Disease nanCOMPLETED
Identifying Biomarkers for Early Detection of Cancer in Patients With Cervical Dysplasia or Carcinoma in Situ of the Cervix nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
CP-EDIT: Cerebral Palsy - Early Diagnosis and Intervention Trial nanRECRUITING
Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders nanCOMPLETED
The Contribution of Optical Mapping to the Characterization of Chromosomal Rearrangements in Patients With Neurodevelopmental Disorders nanRECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk nanNOT_YET_RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) nanCOMPLETED
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a PIN4 binder may also engage these)

ProteinNameSimilarity
Q9CWW6 — 1.000 Q9CWW6 →
Q503Y7 — 1.000 Q503Y7 →
B5KFL3 — 1.000 B5KFL3 →
Q6P4K8 — 0.997 Q6P4K8 →
A6QPY8 — 0.988 A6QPY8 →
Q4I665 — 0.939 Q4I665 →
Q4WJM6 — 0.934 Q4WJM6 →
O88506 — 0.926 O88506 →
Q9Z1W9 — 0.922 Q9Z1W9 →
STK39 STE20/SPS1-related proline-alanine-rich protein kinase 0.920 landscape →
Q66HR2 — 0.919 Q66HR2 →
Q5B5W1 — 0.918 Q5B5W1 →
P31322 — 0.918 P31322 →
Q5R7Z5 — 0.918 Q5R7Z5 →
Q3ZBD9 — 0.918 Q3ZBD9 →
Q863I2 — 0.917 Q863I2 →
MAPRE1 Microtubule-associated protein RP/EB family member 1 0.916 landscape →
Q61166 — 0.916 Q61166 →
Q6V291 — 0.915 Q6V291 →
Q9NFP5 — 0.915 Q9NFP5 →
Q6P9R2 — 0.915 Q6P9R2 →
P12369 — 0.914 P12369 →
Q66T82 — 0.914 Q66T82 →
Q5R495 — 0.914 Q5R495 →
Q08E27 — 0.912 Q08E27 →
A0A8I5ZNK2 — 0.911 A0A8I5ZNK2 →
OXSR1 Serine/threonine-protein kinase OSR1 0.911 landscape →
Q61316 — 0.911 Q61316 →
Q5ZLC7 — 0.911 Q5ZLC7 →
Q5U2U0 — 0.910 Q5U2U0 →