Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | GPR6 | P46095 | 1/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683036 | 0.79 | RXFP1 (0.52) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL21701477 | 0.78 | KDM1A (0.47) | SMN1; SMN2NPC1RAB9AMALT1PRSS12 | |
| SCHEMBL21701473 | 0.77 | NPC1 (0.51) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL21701476 | 0.74 | OPRM1 (0.56) | SMN1; SMN2MAPTNPC1GAAALDH1A1 | |
| SCHEMBL8819152 | 0.71 | KDM4D (0.68) | HDAC1MAPTALDH1A1TP53HTT | |
| SCHEMBL10260121 | 0.71 | TSHR (0.64) | SMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL30844442 | 0.70 | POLB (0.53) | HDAC1SMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL209989 | 0.70 | HDAC1 (0.52) | HDAC1NAMPT | |
| SCHEMBL211039 | 0.70 | HDAC1 (0.52) | HDAC1NAMPT | |
| SCHEMBL209988 | 0.70 | HDAC1 (0.52) | HDAC1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |