Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | CCKAR | P32238 | 2/20 | 0.46 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701473 | 0.81 | NPC1 (0.51) | KDM1ANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL21683036 | 0.79 | RXFP1 (0.52) | NPC1LMNARAB9ASMN1; SMN2NAMPT | |
| SCHEMBL21701475 | 0.78 | HDAC1 (0.52) | PRSS12NPC1RAB9ASMN1; SMN2NAMPT | |
| SCHEMBL21701476 | 0.74 | OPRM1 (0.56) | PRSS12NPC1LMNASMN1; SMN2MALT1 | |
| SCHEMBL13701154 | 0.74 | NHERF1 (0.74) | CCKARNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL1308465 | 0.73 | NPC1 (0.59) | CCKARNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL16701639 | 0.71 | NPC1 (0.61) | KDM1ANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6834022 | 0.71 | NPC1 (0.55) | CCKARNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL21682938 | 0.68 | NAMPT (0.49) | NPC1LMNARAB9ANAMPT | |
| SCHEMBL31162733 | 0.68 | FFAR4 (0.59) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |