Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 18/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685684 | 0.88 | MAP4K1 (0.37) | MAP4K1 | |
| SCHEMBL25940756 | 0.82 | MAP4K1 (0.49) | MAP4K1 | |
| SCHEMBL21684281 | 0.79 | MAP4K1 (0.67) | MAP4K1 | |
| SCHEMBL21684278 | 0.79 | MAP4K1 (0.67) | MAP4K1 | |
| SCHEMBL24859756 | 0.78 | MAP4K1 (0.56) | MAP4K1 | |
| SCHEMBL21685330 | 0.77 | MAP4K1 (0.38) | MAP4K1 | |
| SCHEMBL21684352 | 0.77 | FAAH (0.38) | MAP4K1 | |
| SCHEMBL21684418 | 0.77 | MAP4K1 (0.47) | MAP4K1 | |
| SCHEMBL25940402 | 0.74 | MAP4K1 (0.44) | MAP4K1 | |
| SCHEMBL21684437 | 0.74 | MAP4K1 (0.44) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |