Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25942598 | 0.87 | MAP4K1 (0.43) | DHFRDCPSMAPK14MAP4K1MEN1 | |
| SCHEMBL21702996 | 0.80 | DHFR (0.43) | DHFRDCPSMAPK14MEN1ALDH1A1 | |
| SCHEMBL21703333 | 0.80 | MAP4K1 (0.43) | MAPK14MAP4K1 | |
| SCHEMBL21685623 | 0.80 | MAP4K1 (0.56) | MAP4K1 | |
| SCHEMBL25942399 | 0.79 | MAP4K1 (0.44) | MAPK14MAP4K1 | |
| SCHEMBL21703001 | 0.79 | MAP4K1 (0.42) | MAP4K1 | |
| SCHEMBL31304006 | 0.77 | DHFR (0.50) | DHFRDCPSMAPK14MAP4K1MEN1 | |
| SCHEMBL21703359 | 0.77 | MAP4K1 (0.49) | MAPK14MAP4K1 | |
| SCHEMBL21703438 | 0.77 | MAP4K1 (0.41) | MAPK14MAP4K1 | |
| SCHEMBL21703008 | 0.76 | MAP4K1 (0.40) | MAP4K1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |