Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685392 | 0.82 | MAP4K1 (0.45) | MAP4K1 | |
| SCHEMBL21703101 | 0.73 | MAP4K1 (0.41) | MAP4K1ELANEPKMPARP1 | |
| SCHEMBL21703425 | 0.71 | MAP4K1 (0.39) | MAP4K1ELANEPKM | |
| SCHEMBL21703141 | 0.70 | MAP4K1 (0.47) | MAP4K1ELANE | |
| SCHEMBL21703190 | 0.70 | MAP4K1 (0.44) | MAP4K1ELANE | |
| SCHEMBL21684490 | 0.68 | MAP4K1 (0.48) | MAP4K1PKM | |
| SCHEMBL21703267 | 0.68 | MAP4K1 (0.53) | MAP4K1 | |
| SCHEMBL21684586 | 0.67 | MAP4K1 (0.52) | MAP4K1ELANE | |
| SCHEMBL23452918 | 0.67 | MAP4K1 (0.41) | MAP4K1ELANEPKMPARP1 | |
| SCHEMBL25952900 | 0.67 | MAP4K1 (0.51) | MAP4K1ELANEPKMPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |