Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.62 |
| ▸ | UGCG | Q16739 | 6/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.46 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375264 | 0.85 | S1PR1 (0.68) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL2353422 | 0.85 | S1PR1 (0.66) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL1374116 | 0.85 | S1PR1 (0.62) | S1PR1TAOK1TAOK3 | |
| SCHEMBL15905747 | 0.85 | S1PR1 (0.62) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL2353153 | 0.84 | S1PR1 (0.72) | S1PR1TAOK1TAOK3 | |
| SCHEMBL1376155 | 0.82 | S1PR1 (0.73) | S1PR1TAOK1TAOK3NPY5R | |
| SCHEMBL1374544 | 0.82 | UGCG (0.64) | S1PR1UGCG | |
| SCHEMBL1371986 | 0.82 | S1PR1 (0.61) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL1372313 | 0.81 | S1PR1 (0.66) | S1PR1TAOK1TAOK3 | |
| SCHEMBL1374223 | 0.81 | S1PR1 (0.66) | S1PR1TAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |