Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | UGCG | Q16739 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.46 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374584 | 0.89 | S1PR1 (0.59) | S1PR1UGCG | |
| SCHEMBL1375264 | 0.88 | S1PR1 (0.68) | S1PR1UGCGTAOK1TAOK3TDP1 | |
| SCHEMBL1375613 | 0.88 | S1PR1 (0.63) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL2353153 | 0.86 | S1PR1 (0.72) | S1PR1NPC1RAB9ATAOK1TAOK3 | |
| SCHEMBL2170416 | 0.85 | S1PR1 (0.62) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL15905747 | 0.85 | S1PR1 (0.62) | S1PR1GAAUGCGTAOK1TAOK3 | |
| SCHEMBL1374368 | 0.85 | S1PR1 (0.60) | S1PR1UGCGTAOK1TAOK3 | |
| SCHEMBL1373873 | 0.85 | S1PR1 (0.65) | S1PR1NPC1RAB9ATAOK1TAOK3 | |
| SCHEMBL1373878 | 0.85 | S1PR1 (0.65) | S1PR1NPC1RAB9ATAOK1TAOK3 | |
| SCHEMBL13393225 | 0.85 | S1PR1 (0.62) | S1PR1UGCGTAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |