Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19000276 | 0.87 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL21704070 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL30968413 | 0.80 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL4899387 | 0.80 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL23009510 | 0.78 | LMNA (0.47) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL20731027 | 0.78 | KDM4E (0.66) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL4898042 | 0.75 | KDM4E (0.72) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL20731019 | 0.74 | KDM4E (0.43) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL23938077 | 0.74 | HSD17B10 (0.45) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 | |
| SCHEMBL20732102 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |