Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24248162 | 0.84 | CHRNB2 (0.39) | CHRNB2CHRNA4USP28CHRNB4CHRNA3 | |
| SCHEMBL23938406 | 0.79 | ESR1 (0.31) | — | |
| SCHEMBL20731115 | 0.77 | OPRK1 (0.49) | CHRNB2CHRNA4USP28 | |
| SCHEMBL20731114 | 0.77 | OPRK1 (0.49) | CHRNB2CHRNA4USP28 | |
| SCHEMBL20722677 | 0.77 | GRK2 (0.31) | — | |
| SCHEMBL23938395 | 0.76 | — | — | |
| SCHEMBL20731238 | 0.76 | — | — | |
| SCHEMBL21704292 | 0.76 | — | — | |
| SCHEMBL24595730 | 0.76 | CHRNB2 (0.40) | CHRNB2CHRNA4USP28CHRNB4CHRNA3 | |
| SCHEMBL20722671 | 0.75 | HRH3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |