Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174726 | 0.91 | PIK3CD (0.39) | DPP4PIK3CDPNMTMAPK14 | |
| SCHEMBL16270360 | 0.88 | PIK3CD (0.35) | DPP4PIK3CDPNMTMAPK14 | |
| SCHEMBL4174252 | 0.87 | PIK3CD (0.41) | DPP4PIK3CDPNMT | |
| SCHEMBL4176003 | 0.85 | P2RX7 (0.39) | DPP4PIK3CDPNMT | |
| SCHEMBL4170606 | 0.84 | PIK3CD (0.46) | DPP4PIK3CDCTSA | |
| SCHEMBL4181524 | 0.82 | DPP4 (0.44) | DPP4CTSAPNMT | |
| SCHEMBL4178087 | 0.81 | DPP4 (0.51) | DPP4PIK3CDPNMT | |
| SCHEMBL4180761 | 0.80 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL4175796 | 0.80 | DPP4 (0.38) | DPP4PIK3CDCTSAPNMT | |
| SCHEMBL4433320 | 0.78 | PIK3CD (0.43) | DPP4PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048265-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048265-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | DPP4 4588/4885PIK3CD 16/4885CTSA 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.