Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174252 | 0.91 | PIK3CD (0.41) | PIK3CDTAAR1DPP4MBNL1 | |
| SCHEMBL4175812 | 0.86 | PIK3CD (0.42) | PIK3CDDPP4MBNL1 | |
| SCHEMBL27781223 | 0.85 | PIK3CD (0.41) | PIK3CDDPP4MBNL1 | |
| SCHEMBL4171072 | 0.85 | PIK3CD (0.42) | PIK3CDMBNL1 | |
| SCHEMBL4441908 | 0.83 | PIK3CD (0.45) | PIK3CDTAAR1DPP4 | |
| SCHEMBL4178087 | 0.82 | DPP4 (0.51) | PIK3CDDPP4 | |
| SCHEMBL4442988 | 0.82 | PIK3CD (0.63) | PIK3CD | |
| SCHEMBL13853095 | 0.79 | PIK3CD (0.38) | PIK3CDDPP4MBNL1 | |
| SCHEMBL21705922 | 0.78 | DPP4 (0.36) | PIK3CDDPP4 | |
| SCHEMBL16585320 | 0.78 | PIK3CD (0.47) | PIK3CDTAAR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |