Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5058258 | 0.98 | EPHX1 (0.36) | EPHX1GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL6860747 | 0.84 | GABRA5 (0.40) | EPHX1GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL6850315 | 0.68 | GABRA5 (0.36) | EPHX1GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL5785736 | 0.67 | EPHX1 (0.33) | EPHX1GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL6854245 | 0.67 | EPHX1 (0.33) | EPHX1GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL5744600 | 0.66 | ALDH1A1 (0.30) | — | |
| SCHEMBL6628424 | 0.66 | APOBEC3A (0.34) | — | |
| SCHEMBL10425659 | 0.64 | MEN1 (0.33) | EPHX1TSHRCYP3A4 | |
| SCHEMBL2775188 | 0.63 | — | — | |
| Piperidine SCHEMBL2675445 | 0.62 | ALDH1A1 (0.60) | EPHX1GABRA1TSHRGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767813-B2 | Preparation method | FERMION OY (FI) | 2010-08-03 | — | — | US | claimed |
| EP-1928883-A2 | PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE | Fermion Oy (FI) | 2008-06-11 | — | — | EP | claimed |
| WO-2006084941-A2 | PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE | FERMION OY (FI) | 2006-08-17 | — | — | WO | claimed |
| EP-2341046-A2 | Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin hydrochloride trihydrate | CADILA HEALTHCARE LIMITED (IN) | 2011-07-06 | — | — | EP | disclosed |
| EP-1928883-A2 | PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE | Fermion Oy (FI) | 2008-06-11 | — | — | EP | disclosed |
| WO-2006084941-A2 | PROCESS FOR THE PREPARATION OF IRINOTECAN HYDROCHLORIDE | FERMION OY (FI) | 2006-08-17 | — | — | WO | disclosed |