Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661146 | 0.80 | S1PR1 (0.37) | S1PR1PIK3CDPIK3CAPIK3CBHSD17B10 | |
| SCHEMBL21708176 | 0.80 | HSD17B10 (0.39) | S1PR1PIK3CDPIK3CAPIK3CBHSD17B10 | |
| SCHEMBL662088 | 0.76 | S1PR1 (0.40) | S1PR1PIK3CDPIK3CAPIK3CBHSD17B10 | |
| SCHEMBL1666066 | 0.69 | MTNR1A (0.37) | S1PR1MTNR1AMTNR1B | |
| SCHEMBL661457 | 0.69 | PPARG (0.39) | KMT2AMTNR1AMTNR1B | |
| SCHEMBL30361134 | 0.69 | PPARG (0.39) | KMT2AMTNR1AMTNR1B | |
| SCHEMBL661964 | 0.68 | TP53 (0.39) | HTTHSD17B10MTNR1AMTNR1BTSHR | |
| SCHEMBL2954970 | 0.67 | MTNR1A (0.44) | HTTKMT2AHSD17B10MTNR1AMTNR1B | |
| SCHEMBL661152 | 0.66 | BRD4 (0.37) | MTNR1AMTNR1BTSHR | |
| SCHEMBL4406896 | 0.66 | MTNR1A (0.33) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3610890-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | The Johns Hopkins University (US) | 2020-02-19 | — | — | EP | disclosed |