⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648497 | 0.88 | NPC1 (0.50) | — | |
| SCHEMBL33105 | 0.86 | L3MBTL1 (0.49) | — | |
| SCHEMBL27742621 | 0.85 | L3MBTL1 (0.48) | — | |
| SCHEMBL306157 | 0.83 | — | — | |
| SCHEMBL12963536 | 0.82 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL12963710 | 0.82 | SMN1; SMN2 (0.44) | — | |
| Hydrochloric Acid SCHEMBL6991855 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL29174570 | 0.81 | PKM (0.46) | — | |
| SCHEMBL4580288 | 0.79 | — | — | |
| SCHEMBL11196251 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12558354-B2 | Tumor necrosis factor alpha (TNF-alpha) small molecule inhibitor | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2026-02-24 | — | — | US | disclosed |
| CN-116354900-B | Chlorothiazole compound containing maleic acid structure, and preparation method and application thereof | 中国农业大学 | 2024-03-12 | — | — | CN | disclosed |
| CN-116354900-A | Chlorothiazole compound containing maleic acid structure, and preparation method and application thereof | 中国农业大学 | 2023-06-30 | — | — | CN | disclosed |
| EP-3601297-B9 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2023-05-24 | — | — | EP | disclosed |
| US-20230000861-A1 | TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) SMALL MOLECULE INHIBITOR | AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2023-01-05 | — | — | US | disclosed |
| US-20180065966-A1 | Antimicrobial Compounds And Methods Of Making And Using The Same | MELINTA THERAPEUTICS, INC. | 2018-03-08 | — | — | US | disclosed |
| WO-2016145417-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS, INC. (US) | 2016-09-15 | — | — | WO | disclosed |
| CN-104356090-B | Thiazole derivative of a kind of glaucocalyxin A and its preparation method and application | XINXIANG MEDICAL COLLEGE (CN) | 2016-04-06 | — | — | CN | disclosed |
| CN-104356090-A | Glaucocalyxin A thiazole derivative, preparation method and application thereof | UNIV XINXIANG MEDICAL | 2015-02-18 | — | — | CN | disclosed |
| EP-2346868-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-20050080083-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and an angiotensin II receptor antagonist for the treatment of central nervous system damage | PHARMACIA CORPORATION (US) | 2005-04-14 | — | — | US | disclosed |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | disclosed |
| US-20050075341-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and an IKK inhibitor for the treatment of ischemic mediated central nervous system disorders or injury | PHARMACIA CORPORATION (US) | 2005-04-07 | — | — | US | disclosed |
| US-20050070524-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders | PHARMACIA CORPORATION | 2005-03-31 | — | — | US | disclosed |
| US-20050026902-A1 | Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents | PHARMACIA CORPORATION | 2005-02-03 | — | — | US | disclosed |
| US-20050026919-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a cholinergic agent for the treatment of reduced blood flow or trauma to the central nervous system | PHARMACIA CORPORATION | 2005-02-03 | — | — | US | disclosed |
| EP-1021411-B1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6326386-B1 | ANTICOAGULANT | GLAXO GROUP LIMITED (GB) | 2001-12-04 | — | — | US | disclosed |
| EP-1021411-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997022589-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |