Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21730038 | 0.93 | KDM4E (0.59) | SIGMAR1HTR2BSMN1; SMN2TSHR | |
| SCHEMBL14420826 | 0.84 | POLB (0.67) | POLBNPC1SMN1; SMN2DRD1DRD4 | |
| SCHEMBL21709942 | 0.84 | DRD1 (0.54) | POLBNPC1SIGMAR1HTR2BSMN1; SMN2 | |
| SCHEMBL21730110 | 0.83 | NPC1 (0.53) | POLBNPC1SIGMAR1RAB9ADRD1 | |
| SCHEMBL21730016 | 0.83 | MEN1 (0.59) | POLBNPC1SIGMAR1HTR2BRAB9A | |
| SCHEMBL12058633 | 0.82 | TDP1 (0.74) | POLBNPC1SMN1; SMN2RAB9ADRD1 | |
| SCHEMBL21730018 | 0.82 | POLB (0.54) | POLBNPC1SMN1; SMN2DRD1DRD4 | |
| SCHEMBL15872036 | 0.80 | SMN1; SMN2 (0.74) | POLBNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL21730017 | 0.80 | ALDH1A1 (0.51) | NPC1SIGMAR1HTR2BRAB9ADRD1 | |
| SCHEMBL21681926 | 0.79 | POLB (0.62) | POLBNPC1SMN1; SMN2RAB9ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036574-A1 | ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I' PATHWAY AND METHODS OF USE THEREOF | Kineta, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |
| WO-2020033782-A1 | ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-1\" PATHWAY AND METHODS OF USE THEREOF | Kineta, Inc. (US) | 2020-02-13 | — | — | WO | disclosed |