Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171015 | 0.88 | NPC1 (0.65) | POLBSYKALDH1A1NPC1TSHR | |
| Hydrochloric Acid SCHEMBL5888564 | 0.87 | POLB (0.59) | POLBSYKALDH1A1NPC1TSHR | |
| Hydrochloric Acid SCHEMBL5888035 | 0.87 | POLB (0.59) | POLBSYKALDH1A1NPC1TSHR | |
| SCHEMBL14416658 | 0.86 | MEN1 (0.65) | POLBSYKALDH1A1NPC1TSHR | |
| Hydrochloric Acid SCHEMBL5888563 | 0.86 | POLB (0.58) | POLBSYKALDH1A1NPC1TSHR | |
| SCHEMBL12845584 | 0.85 | SYK (0.64) | POLBSYKALDH1A1NPC1TSHR | |
| SCHEMBL13849354 | 0.85 | SYK (0.64) | POLBSYKALDH1A1NPC1TSHR | |
| SCHEMBL21709877 | 0.84 | POLB (0.59) | POLBSYKNPC1TSHRSMN1; SMN2 | |
| SCHEMBL15872036 | 0.83 | SMN1; SMN2 (0.74) | POLBSYKALDH1A1NPC1TSHR | |
| SCHEMBL13744602 | 0.82 | NPC1 (0.65) | POLBSYKALDH1A1NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225287-A1 | Substituted Arylpyrazines | YOON TAEYOUNG | 2007-09-27 | — | — | US | disclosed |
| US-7202250-B2 | Substituted arylpyrazines | NEUROGEN CORPORATION (US) | 2007-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225287-A1 | Substituted Arylpyrazines | CRHR1, CRHR2, CRH | POLB 4841/4885SYK 4582/4885ALDH1A1 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.