SCHEMBL2171152

SCHEMBL2171152

O=[C]OCCC(c1ccccc1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 6/20 0.45
HTR2A P28223 6/20 0.42
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
CNR1 P21554 2/20 0.38
EPHX2 P34913 1/20 0.38
CNR2 P34972 1/20 0.38
KCNH2 Q12809 2/20 0.37
CYP3A4 P08684 2/20 0.37
CHRM2 P08172 1/20 0.37
HTR1A P08908 1/20 0.37
ADRA2A P08913 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
CHRM1 P11229 1/20 0.37
SMPD1 P17405 1/20 0.37
DRD1 P21728 1/20 0.37
TBXA2R P21731 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9572884 0.82 RIPK1 (0.47) TAAR1ALDH1A1
SCHEMBL9572983 0.80 CCR5 (0.40) TAAR1CYP3A4CHRM2CHRM1LMNA
SCHEMBL1683176 0.78 CA12 (0.42) HRH1HTR2ATAAR1CYP3A4CYP1A2
SCHEMBL9572898 0.78 AOC3 (0.36) CHRM2CHRM1LMNACYP1A2CYP2D6
SCHEMBL2092257 0.76 RIPK1 (0.44) TAAR1ALDH1A1
SCHEMBL29280865 0.75 HRH1 (0.54) HRH1HTR2AMTNR1AMTNR1BTAAR1
SCHEMBL2421009 0.75 HRH1 (0.54) HRH1HTR2AMTNR1AMTNR1BTAAR1
SCHEMBL9572677 0.74 RIPK1 (0.43) TAAR1ALDH1A1SIGMAR1
SCHEMBL9572673 0.73 CCR5 (0.38) TAAR1CHRM2CHRM1LMNACYP1A2
SCHEMBL96855 0.73 SCN1A (0.40) HRH1HTR2ATAAR1KCNH2CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2346877-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE Tibotec Pharmaceuticals (IE) 2011-07-27 EP disclosed
WO-2010023322-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE TIBOTEC PHARMACEUTICALS (IE) 2010-03-04 WO disclosed
EP-0203723-A1 2,3-(dihydro)bicyclic pyrazolidinones ELI LILLY AND COMPANY (US) 1986-12-03 EP disclosed