Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13615359 | 0.80 | CYP1A2 (0.67) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL20673417 | 0.79 | CYP2C9 (0.53) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL16060163 | 0.76 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL21981602 | 0.76 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL4343263 | 0.74 | BACE1 (0.52) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL20659684 | 0.73 | KDM2B (0.47) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL20659621 | 0.73 | CYP2C9 (0.38) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL16061971 | 0.72 | ALDH1A1 (0.49) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL20659623 | 0.72 | LMNA (0.45) | CYP1A2CYP2C9CYP2C19KDM4EMAPT | |
| SCHEMBL21713129 | 0.71 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
| US-20200054617-A1 | Heteroaromatic Carboxamide Derivatives as Plasma Kallikrein Inhibitors | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200054617-A1 | Heteroaromatic Carboxamide Derivatives as Plasma Kallikrein Inhibitors | KLKB1, KLK1, KLK5 | CYP1A2 400/4885CYP2C9 444/4885CYP2C19 180/4885 |
| US-10695334-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | KLKB1, KLK1, KLK5 | CYP1A2 400/4885CYP2C9 444/4885CYP2C19 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.