Sugi Predict

Sugi Predict / Compounds / SCHEMBL21713244

SCHEMBL21713244

SCHEMBL21713244

Cc1ccc(S(=O)(=O)OC2=CCCN(C(=O)OC(C)(C)C)C2)cc1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ MMP13 P45452 1/20 0.43
▸ GPR119 Q8TDV5 5/20 0.43
▸ P2RX7 Q99572 2/20 0.43
▸ STS P08842 3/20 0.41
▸ MAPK1 P28482 1/20 0.40
▸ ESR2 Q92731 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ NR1H2 P55055 1/20 0.38
▸ F13A1 P00488 1/20 0.38
▸ TGM2 P21980 1/20 0.38
▸ TGM1 P22735 1/20 0.38
▸ STAT3 P40763 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15139180 0.81 ESR2 (0.41) GPR119STSMAPK1ESR2ALDH1A1
SCHEMBL1439920 0.78 ESR2 (0.39) GPR119STSMAPK1ESR2ALDH1A1
SCHEMBL21713210 0.75 KMT2A (0.41) KMT2AMEN1MMP13GPR119P2RX7
SCHEMBL3312151 0.75 KMT2A (0.39) KMT2AMEN1MMP13GPR119P2RX7
SCHEMBL19780861 0.74 KMT2A (0.38) KMT2AMEN1MMP13GPR119P2RX7
SCHEMBL216692 0.73 GPR119 (0.58) KMT2AMEN1MMP13GPR119STS
SCHEMBL13618035 0.73 GPR119 (0.55) KMT2AMEN1MMP13GPR119STS
SCHEMBL2455910 0.73 GPR119 (0.41) KMT2AMEN1MMP13GPR119P2RX7
SCHEMBL12519920 0.72 ESR2 (0.47) KMT2AMEN1GPR119MAPK1ESR2
SCHEMBL184777 0.72 CYP2D6 (0.60) KMT2AMEN1MMP13GPR119STS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118271233-A Nilaparil manufacturing method 特沙诺有限公司 2024-07-02 — — CN disclosed
US-11629137-B2 Methods of manufacturing of niraparib TESARO, INC. (US) 2023-04-18 — — US disclosed
EP-3615513-B1 METHODS OF MANUFACTURING OF NIRAPARIB TESARO INC (US) 2022-07-20 — — EP disclosed
US-20220041575-A1 METHODS OF MANUFACTURING OF NIRAPARIB TESARO, INC. 2022-02-10 — — US disclosed
US-11161834-B2 Methods of manufacturing of niraparib TESARO, INC. (US) 2021-11-02 — — US disclosed
US-20200055837-A1 METHODS OF MANUFACTURING OF NIRAPARIB TESARO, INC. 2020-02-20 — — US disclosed
CN-110753684-A Method for producing nilapali 特沙诺有限公司 2020-02-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055837-A1 METHODS OF MANUFACTURING OF NIRAPARIB PARP2, PARP1, PARP3 KMT2A 182/4885MEN1 2505/4885MMP13 1820/4885
US-20220041575-A1 METHODS OF MANUFACTURING OF NIRAPARIB PARP2, PARP1, PARP3 KMT2A 182/4885MEN1 2505/4885MMP13 1820/4885
US-11161834-B2 Methods of manufacturing of niraparib PARP2, PARP1, PARP3 KMT2A 182/4885MEN1 2505/4885MMP13 1820/4885
US-11629137-B2 Methods of manufacturing of niraparib PARP2, PARP1, PARP3 KMT2A 182/4885MEN1 2505/4885MMP13 1820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.