Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18966171 | 0.98 | LTA4H (0.47) | LTA4HEPHX2FFAR1PPARGPPARA | |
| SCHEMBL2170992 | 0.90 | FFAR1 (0.53) | LTA4HEPHX2FFAR1PPARGPPARA | |
| SCHEMBL1478337 | 0.90 | NAAA (0.51) | FFAR1MPONAAALMNA | |
| SCHEMBL27484744 | 0.88 | NAAA (0.50) | FFAR1MPONAAALMNA | |
| SCHEMBL29655601 | 0.88 | NAAA (0.50) | FFAR1MPONAAALMNA | |
| SCHEMBL31577212 | 0.88 | NAAA (0.50) | FFAR1MPONAAALMNA | |
| SCHEMBL29655674 | 0.88 | NAAA (0.50) | FFAR1MPONAAALMNA | |
| SCHEMBL10327442 | 0.86 | MAPT (0.57) | LTA4HEPHX2FFAR1PPARGPPARA | |
| SCHEMBL9094542 | 0.85 | FFAR1 (0.65) | LTA4HFFAR1PPARGPARP10FFAR4 | |
| SCHEMBL10327290 | 0.84 | LTA4H (0.46) | LTA4HEPHX2FFAR1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |