Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.61 |
| ▸ | JAK2 | O60674 | 11/20 | 0.61 |
| ▸ | JAK3 | P52333 | 7/20 | 0.61 |
| ▸ | TYK2 | P29597 | 5/20 | 0.61 |
| ▸ | ATR | Q13535 | 4/20 | 0.49 |
| ▸ | ATRIP | Q8WXE1 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21714165 | 0.85 | JAK1 (0.59) | JAK1JAK2JAK3TYK2ATR | |
| SCHEMBL28345574 | 0.81 | JAK1 (0.70) | JAK1JAK2JAK3TYK2ATR | |
| SCHEMBL21714463 | 0.80 | CCNT1 (0.52) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL23153249 | 0.79 | JAK2 (0.47) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL21714188 | 0.77 | HSD11B1 (0.54) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL16477352 | 0.76 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL21714258 | 0.76 | GPR119 (0.42) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL23029209 | 0.76 | JAK1 (0.75) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL14697120 | 0.75 | JAK3 (0.61) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL30945082 | 0.75 | JAK1 (0.61) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | claimed |
| US-20200055847-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2020-02-20 | — | — | US | claimed |
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | disclosed |
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | disclosed |
| US-20200055847-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | SHH, GLI1, SMO | JAK1 119/4885JAK2 143/4885JAK3 196/4885 |
| US-20200055847-A1 | MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | SHH, GLI1, SMO | JAK1 107/4885JAK2 148/4885JAK3 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.