Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | GRB2 | P62993 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.33 |
| ▸ | PROC | P04070 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21715626 | 0.87 | MMP1 (0.42) | MMP1CTSBGRB2MMP2MMP3 | |
| SCHEMBL25356787 | 0.72 | PLA2G10 (0.51) | PLA2G10PLA2G2ADPP4 | |
| SCHEMBL25356783 | 0.72 | PLA2G10 (0.51) | PLA2G10PLA2G2ADPP4 | |
| SCHEMBL25357735 | 0.72 | PLA2G10 (0.51) | PLA2G10PLA2G2ADPP4 | |
| SCHEMBL27272143 | 0.72 | PLA2G10 (0.47) | PLA2G10PLA2G2ADPP4 | |
| SCHEMBL21683255 | 0.66 | CTSS (0.45) | CTSBCTSLCTSSCTSK | |
| SCHEMBL21683256 | 0.66 | CTSS (0.45) | CTSBCTSLCTSSCTSK | |
| SCHEMBL13979533 | 0.66 | MMP1 (0.50) | MMP1CTSBCTSLCTSSCTSK | |
| SCHEMBL23924939 | 0.66 | GRB2 (0.43) | GRB2HDAC1HDAC6 | |
| SCHEMBL23924937 | 0.66 | GRB2 (0.43) | GRB2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033317-A1 | PIPERAZINE-2,5-DIONES AS TGF-BETA INHIBITORS | SOUTHERN RESEARCH INSTITUTE (US) | 2020-02-13 | — | — | WO | disclosed |