Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794207 | 0.89 | EPHX1 (0.58) | EPHX1APPADRB2FFAR2KMT2A | |
| SCHEMBL607802 | 0.89 | EPHX1 (0.58) | EPHX1APPADRB2FFAR2KMT2A | |
| SCHEMBL607803 | 0.89 | EPHX1 (0.58) | EPHX1APPADRB2FFAR2KMT2A | |
| SCHEMBL2170913 | 0.85 | P2RX4 (0.49) | APPFNTAFNTBFFAR1KMT2A | |
| SCHEMBL2169718 | 0.84 | PARP10 (0.58) | EPHX1PTGS2KMT2APARP10PARP4 | |
| SCHEMBL13235878 | 0.84 | BRD4 (0.50) | MAOAMAOBFNTAFNTBFFAR1 | |
| SCHEMBL2172240 | 0.84 | EPHX1 (0.50) | EPHX1FNTAFNTBPOLBALDH1A1 | |
| SCHEMBL2173030 | 0.84 | PARP10 (0.55) | EPHX1PTGS2FFAR1NPY5RKMT2A | |
| SCHEMBL5787219 | 0.84 | EPHX1 (0.53) | EPHX1APPPTGS2FFAR1ADRB2 | |
| SCHEMBL2171467 | 0.84 | FFAR1 (0.57) | APPPTGS2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |