Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054675 | 0.89 | EPHX1 (0.60) | EPHX1ALOX5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL16750533 | 0.89 | EPHX1 (0.60) | EPHX1ALOX5ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL2169718 | 0.86 | PARP10 (0.58) | EPHX1LTA4HALOX5MAPTKMT2A | |
| SCHEMBL2173030 | 0.86 | PARP10 (0.55) | EPHX1ALOX5KMT2APARP10SMN1; SMN2 | |
| SCHEMBL2170990 | 0.84 | EPHX1 (0.49) | EPHX1ALDH1A1 | |
| SCHEMBL2171656 | 0.84 | EPHX1 (0.49) | EPHX1ALDH1A1POLBKMT2APARP10 | |
| SCHEMBL1824947 | 0.80 | KMT2A (0.51) | EPHX1ALDH1A1MAPTKMT2AHTT | |
| SCHEMBL2370549 | 0.79 | EPHX1 (0.55) | EPHX1ALOX5MAPTKMT2APARP10 | |
| SCHEMBL2055565 | 0.79 | EPHX1 (0.55) | EPHX1ALOX5MAPTKMT2APARP10 | |
| SCHEMBL2170913 | 0.77 | P2RX4 (0.49) | ALOX5KMT2APARP10PARP15PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |