Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169515 | 1.00 | CNR2 (0.51) | CNR2CHRNB4CHRNA3LTA4HIRAK4 | |
| SCHEMBL2170542 | 0.97 | LTA4H (0.55) | CNR2CHRNB4CHRNA3LTA4HIRAK4 | |
| SCHEMBL3622371 | 0.84 | IRAK4 (0.52) | CNR2IRAK4SCN8ASCN10ATSHR | |
| SCHEMBL2170111 | 0.82 | IRAK4 (0.53) | IRAK4SCN8ASCN10A | |
| SCHEMBL13602330 | 0.81 | LTA4H (0.56) | CNR2CHRNB4CHRNA3LTA4H | |
| SCHEMBL10560065 | 0.80 | LTA4H (0.55) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL3477127 | 0.77 | TSHR (0.66) | CNR2IRAK4SCN10ATSHR | |
| SCHEMBL3159343 | 0.76 | LTA4H (0.51) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL3627815 | 0.76 | CNR2 (0.59) | CNR2CHRNB4CHRNA3IRAK4MAP2K1 | |
| SCHEMBL1974220 | 0.76 | CNR2 (0.59) | CNR2CHRNB4CHRNA3IRAK4MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346843-A2 | SUBSTITUTED BENZAMIDES AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010028338-A2 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2010-03-11 | — | — | WO | disclosed |