Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173919 | 0.88 | GPBAR1 (0.44) | TP53PIK3CAGPBAR1MAPTCYP3A4 | |
| SCHEMBL2173329 | 0.87 | GPBAR1 (0.47) | TP53PIK3CAGPBAR1MAPTKDM4E | |
| SCHEMBL2171308 | 0.86 | PIK3CA (0.53) | TP53PIK3CAGPBAR1MAPTKDM4E | |
| SCHEMBL2172957 | 0.82 | PIK3CA (0.53) | PIK3CAGPBAR1KDM4EALDH1A1ALPL | |
| SCHEMBL2174569 | 0.81 | MAPT (0.60) | TP53PIK3CAGPBAR1MAPTKDM4E | |
| SCHEMBL2170968 | 0.80 | TP53 (0.46) | TP53PIK3CAGPBAR1MAPTTHRB | |
| SCHEMBL2171314 | 0.80 | GPBAR1 (0.47) | TP53PIK3CAGPBAR1MAPTALDH1A1 | |
| SCHEMBL2172385 | 0.80 | KDM4E (0.39) | TP53PIK3CAGPBAR1MAPTKDM4E | |
| SCHEMBL2173419 | 0.79 | TP53 (0.44) | TP53PIK3CAGPBAR1MAPTTHRB | |
| SCHEMBL2171240 | 0.78 | KDM4E (0.39) | TP53PIK3CAGPBAR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |