Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172365 | 0.86 | HCRTR2 (0.40) | KDM4EALDH1A1ALPLHSD17B10GLA | |
| SCHEMBL2171240 | 0.85 | KDM4E (0.39) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2173329 | 0.84 | GPBAR1 (0.47) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2172957 | 0.83 | PIK3CA (0.53) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2173919 | 0.83 | GPBAR1 (0.44) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2171484 | 0.82 | POLB (0.49) | PIK3CATP53MAPTKMT2AGPBAR1 | |
| SCHEMBL2172245 | 0.80 | TP53 (0.41) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2172003 | 0.80 | TP53 (0.42) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2173092 | 0.78 | PIK3CA (0.44) | KDM4EALDH1A1ALPLHSD17B10PIK3CA | |
| SCHEMBL2173538 | 0.78 | TP53 (0.44) | KDM4EALDH1A1ALPLHSD17B10NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |