Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173329 | 0.85 | GPBAR1 (0.47) | MAPTTP53POLBPIK3CAHSD17B1 | |
| SCHEMBL2171314 | 0.83 | GPBAR1 (0.47) | MAPTTP53PIK3CAHSD17B1HSD17B2 | |
| SCHEMBL2173919 | 0.80 | GPBAR1 (0.44) | MAPTTP53PIK3CAKDM4EALDH1A1 | |
| SCHEMBL2173419 | 0.77 | TP53 (0.44) | MAPTTP53PIK3CAHSD17B1HSD17B2 | |
| SCHEMBL2172245 | 0.77 | TP53 (0.41) | MAPTTP53PIK3CAKDM4EALDH1A1 | |
| SCHEMBL2170968 | 0.76 | TP53 (0.46) | MAPTTP53PIK3CAHSD17B1HSD17B2 | |
| SCHEMBL2172957 | 0.76 | PIK3CA (0.53) | POLBPIK3CAKDM4EALDH1A1GLA | |
| SCHEMBL2172385 | 0.74 | KDM4E (0.39) | MAPTTP53PIK3CAKDM4EALDH1A1 | |
| SCHEMBL2171482 | 0.73 | KDM4E (0.59) | POLBKDM4EALDH1A1GLAGAA | |
| SCHEMBL2171240 | 0.73 | KDM4E (0.39) | MAPTTP53POLBPIK3CAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |