Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.55 |
| ▸ | FNTB | P49356 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171203 | 0.92 | HDAC1 (0.71) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL9240178 | 0.83 | HDAC1 (0.83) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2170220 | 0.83 | TRPV1 (0.64) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL3255173 | 0.82 | MAPT (0.77) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL1371901 | 0.81 | S1PR1 (0.66) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL1371904 | 0.81 | S1PR1 (0.66) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL20942366 | 0.81 | RNF4 (0.67) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL28099312 | 0.80 | MAPT (0.74) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL2171356 | 0.80 | MTNR1B (0.66) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL7451167 | 0.79 | HDAC1 (0.70) | HDAC1HDAC3HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |