Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2217005 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL27641686 | 0.75 | GAA (0.62) | POLBTSHRHCAR2MAPTGAA | |
| SCHEMBL9266536 | 0.72 | KDM4E (0.46) | POLBTSHRALOX15KDM4ENAPRT | |
| SCHEMBL29556324 | 0.70 | KDM4E (0.61) | POLBCYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL875263 | 0.70 | KDM4E (0.61) | POLBCYP1A2CYP2C9CYP2C19TSHR | |
| Morinamide SCHEMBL563960 | 0.70 | GFER (0.67) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL552688 | 0.70 | KDM4E (0.55) | POLBCYP1A2CYP2C9CYP2C19TSHR | |
| Morinamide SCHEMBL29464523 | 0.70 | GFER (0.67) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL11779790 | 0.69 | KDM4E (0.59) | POLBCYP1A2CYP2C9CYP2C19TSHR | |
| Morinamide SCHEMBL1650433 | 0.69 | GFER (0.66) | NPC1RAB9APOLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |