Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Morinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morinamide SCHEMBL29464523 | 0.99 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| Morinamide SCHEMBL563960 | 0.99 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| Morinamide SCHEMBL2270538 | 0.97 | GFER (0.66) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL26922576 | 0.85 | SMN1; SMN2 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29834822 | 0.85 | SMN1; SMN2 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL26921832 | 0.85 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL29834783 | 0.85 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL26921315 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL31086880 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL29834871 | 0.82 | GFER (0.64) | GFERALDH1A1KDM4ETAAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |